Thank you John and guests for bringing information about Vitamin-D3 to light. The following quote is always apt in these situations. It is relevant to every population outside of the tropics.
"Because vitamin D is so cheap so clearly reduces all-cause mortality, I can say this with great certainty: Vitamin D represents single most cost-effective medical intervention in the United States." - Dr. Gregg Plotnikoff circa 2010
There is a very good site with collected Vitamin-D3 information about diseases that has been around for over a decade with extracts from thousands of papers. The site maintainer Henry Lahore is also here on Substack with the stack "Science-based Vitamin D"
There is the seminal site collecting efficacy of treatments and prophylactics for covid that has over 100 papers with treatment with Vitamin-D3 that shows overwhelming benefit. Cost of using Vitamin-D3 is at the low end. Using Calcifediol in critical situations is probably prudent where possible but usually not required if the regular supplementation is at a reasonable physiological level. Select the Vitamin-D menu option to drill down, however the whole site is very informative.
Then my small collection of extracts and highlights from various papers referring to Vitamin-D3 and covid that I started in February 2021 and mostly stopped at about 100 studies because there is no point in getting more whips to flog a dead horse, Vitamin-D3 works and if you will not believe 100 studies then you are brainwashed.
I was in the oncology ward last summer and pointed out that the cancer guide from the Canadian federal agency pointed out that it helps fight cancer. Some of my friends offered to bring some in but, they actually added vitamin D to my prescription. I had to show evidence for it, in brochures from walls in the hospital, lol. They should be giving it to everyone in oncology by default. IMHO. Or at least check your level. I mean the seem to take blood every other hour any way.
I've been a strong advocate of Dr Campbell for the past 3+ yrs and for vitamin D longer.
However I've recently noted that my comments on his videos, of which I've viewed hundreds and shared with others, have strangely disappeared. I can only assume edited out.
This despite being supportive. For example, in one ~3 days ago on mRNA vaccine which caused the thing it tries to prevent, I quoted that Govt evidence shows the covid vaccine increased covid by up to 3.5x.
If such supportive comments are unwanted for some reason, I will unsubscribe and stop recommending the site.
There is very little vitamin D3 in food, including foods fortified with vitamin D3 (vitamin D2 is less effective than D3, and is often used in fortified food).
Vitamin De can be produced in substantial quantities from UV-B exposure of ideally white skin, but this is not naturally available all year round to most people who live far from the equator, since it requires high elevation sunlight without cloud, glass, clothing or sunscreen. Furthermore, UV-B skin exposure always damages DNA and so raises the risk of skin cancer. In a given day, there is no extra benefit of being exposed to about 1/3 of the amount of UV-B which is required to redden the skin.
Consequently, most people cannot be fully healthy without proper vitamin D3 supplementation. The quantities are small, but are 5 to 10 times what most medical professionals think is adequate, because they are only aiming for 20 ng/mL circulating 25-hydroxyvitamin D which is sufficient to supply the kidneys.
Please see the research on the vitamin D compounds and the immune system cited and discussed at: https://vitamindstopscovid.info/00-evi/. This includes recommendations for how much vitamin D3 to supplement in order to attain this. The amount depends on body weight, with higher ratios of body weight for those suffering from obesity.
These are the recommendations of New Jersey based Professor of Medicine, Sunil Wimalawansa, as recently published in an article co-written by two other long-time vitamin D researchers, one also a professor of medicine and the other a professor of pediatrics: https://www.mdpi.com/2072-6643/16/22/3969
People suffering from obesity needing more supplemental vitamin D3 as a ratio of bodyweight to attain at least 50 ng/mL circulating 25-hydroxyvitamin D are detailed here: https://5nn.info/temp/250hd-obesity/. Obesity reduced the hydroxylation of vitamin D3 cholecalciferol in the liver to the circulating 25-hydroxyvitamin D the immune system needs and the excess adipose tissue absorbs this circulating25-hydroxyvitamin D.
0.125 mg (5000 IU) vitamin D3 a day on average is sufficient for 70 kg 154 lb body weight without obesity.
Without proper vitamin D3 supplementation such as this, most people - at least in winter - have half or less (down to 1/10th) of the 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D they need to be healthy.
"5000 IUs a day" sounds like a lot, but it is 1/8000th of a gram = 1 gram every 22 years. Pharma grade vitamin D3 costs about USD$2.50 a gram ex-factory. A credit card weighs 5 grams.
25-hydroxyvitamin D (calcifediol AKA "calcidiol") is made, primarily in the liver, from ingested or UV-B -> skin produced vitamin D3 cholecalciferol. This takes several days and only about 1/4 of ingested vitamin D3 is hydroxylated to become circulating 25-hydroxyvitamin D, as measured in "vitamin D" blood tests.
Neither of these compounds act as hormones. They are not signaling molecules. The immune system does not use hormonal signaling.
Many types of immune cell need a good supply of 25-hydroxyvitamin D in order to run their intracrine (inside each cell) and paracrine (to nearby cells) signaling systems, which are crucial to the cell's ability to respond to its changing circumstances.
Not long after lockdown in Aus ended, I took my teenage daughter for blood tests - iron etc. when we went back to results I asked what her Vit D levels were. I was told they no longer test for that in a general panel of bloods due to Government directive. The GP went on to say that Vit D levels are only relevant in old age / brittle bones
Yes, I recently asked my doctor to check and she said no, as they routinely assume everyone is deficient. However, they also warn that excess is toxic--how is one to determine proper dosage?
The haplotypes of the mitochondria in different populations will determine the coupling effects in cellular processes linked to Vitamin D synthesis and the environment a person is best suited. If you have a coupled type living near the equator is best or you will need to mitigate with other strategies like lamps, etc. It also makes a difference in the type of diet you eat. I would highly recommend having Dr. Jack Kruse on. He is a plethora of knowledge Dr. Campbell.
When you engage, they don't reason, they just spout nonsense.
As far as I am concerned it is inflammatory hyperbole combined with deliberate factual inaccuracies designed to put the trusting reader off taking supplements. The game plan appears to be ANY supplements.
Now, I don't pretend all supplements are high quality and ethical by any means, but these people are LYING.
"For possum control, cholecalciferol has been used as the active ingredient in lethal baits. The LD50 is 16.8 mg/kg, but only 9.8 mg/kg if calcium carbonate is added to the bait. Kidneys and heart are target organs. LD50 of 4.4 mg/kg has been reported in rabbits, with lethality to almost all rabbits ingesting doses greater than 15 mg/kg. Toxicity has been reported across a wide range of cholecalciferol dosages, with LD50 as high as 88 mg/kg or LDLo as low as 2 mg/kg reported for dogs."
"Toxic doses of cholecalciferol are much lower than reported acute lethal doses (13 mg/kg) and median lethal doses (88 mg/kg), and important clinical changes with notable morbidity, even mortality, may be noted with relatively low doses. Therefore the acute lethal dose and median lethal dose are recognized, but they are rarely used in guiding aggressive care and monitoring in companion animal patients. Clinical signs may be noted in doses as low as 0.1 mg/kg, with appreciable elevations in calcium and phosphorus concentrations leading to metastatic soft tissue mineralization in doses exceeding 0.5 mg/kg."
Karl, the fact cholecalciferol can be used as a rodenticide does not make it ipso facto a rat poison.
You seem to blithely ignore the simple fact we produce the EXACT same chemical endogenously every time we step out into the sun (physiology willing, and despite Bill Gates).
Do me the courtesy of reading my single post on this matter, reply to the points therein, or shut up.
well, the same companies (big pharma) produce the chemical and sell it both as a rat poison and a human supplement. the recommended levels of this chemical in our blood was suddenly changed in 2011 and that's when the human supplement market took off. here's an article about how it started and who's behind it (yes, it's big pharma).
Amazingly !!! good YouTube video by John Campbell - the best ever? I am an MD aa well as a PhD. I do have suggestions for John Campbell about people to interview but how can I come in direct contact with him?
One of whom is a Swedish MD PhD and "vitamin D enthusiast" with published papers in the field. And the others two psychology PhD:s and professors from Canada an New Zealand with many published papers on "nutrition" and mental disorders.
Now 77. Began supplementing with daily 5k iu D3 plus K2 in 2020. Blood level rose to 50 ng/ml within a few months. Now at 74 ng/ml. No vaxes of any kind for 20 plus years. No respiratory illnesses except mild case of Covid last fall temp ~100 and tired for a week.
I live on the equator so you would think D would be plentiful, but at altitude there is so much cloud cover that everyone takes D. It's sold everywhere... supermarkets, drug stores, shops and bodegas. They are large orange tablets that dissolve in water like an Alma Seltzer or Fizzie. C, D and Zinc. It's a once a day ritual here. I also spend twenty minutes a day with a Vitamin D lamp. Are the lamps considered effective? Amazon has several to choose from in the $19. range.
Dear Dcotor Campbell, I can only ask you to translate this German article:
It is the first part, which deals exclusively with the pharmacokinetics of LNPs and modRNA. The second part, which is currently in progress (220+ studies and reviews by now and still no end inside), will provide a ruthless assessment of pharmacodynamics and a discussion of whether this technology should ever have been unleashed on humanity:
When I had my Aorta replaced the surgeon said. “Your vitamin D is so good for someone of your age”. “What do you do”. I replied I’m always in the sun and drink cows milk and eat cheese.
Thank you John and guests for bringing information about Vitamin-D3 to light. The following quote is always apt in these situations. It is relevant to every population outside of the tropics.
"Because vitamin D is so cheap so clearly reduces all-cause mortality, I can say this with great certainty: Vitamin D represents single most cost-effective medical intervention in the United States." - Dr. Gregg Plotnikoff circa 2010
There is a very good site with collected Vitamin-D3 information about diseases that has been around for over a decade with extracts from thousands of papers. The site maintainer Henry Lahore is also here on Substack with the stack "Science-based Vitamin D"
https://www.vitamindwiki.com
There is the seminal site collecting efficacy of treatments and prophylactics for covid that has over 100 papers with treatment with Vitamin-D3 that shows overwhelming benefit. Cost of using Vitamin-D3 is at the low end. Using Calcifediol in critical situations is probably prudent where possible but usually not required if the regular supplementation is at a reasonable physiological level. Select the Vitamin-D menu option to drill down, however the whole site is very informative.
https://c19early.org
Then my small collection of extracts and highlights from various papers referring to Vitamin-D3 and covid that I started in February 2021 and mostly stopped at about 100 studies because there is no point in getting more whips to flog a dead horse, Vitamin-D3 works and if you will not believe 100 studies then you are brainwashed.
https://cholecalciferol.miraheze.org/wiki/DOI
MS nurses tell newly diagnosed young women to start taking VitD as they are usually very deficient. MS seems to be worse in more northerly latitudes.
I was in the oncology ward last summer and pointed out that the cancer guide from the Canadian federal agency pointed out that it helps fight cancer. Some of my friends offered to bring some in but, they actually added vitamin D to my prescription. I had to show evidence for it, in brochures from walls in the hospital, lol. They should be giving it to everyone in oncology by default. IMHO. Or at least check your level. I mean the seem to take blood every other hour any way.
I've been a strong advocate of Dr Campbell for the past 3+ yrs and for vitamin D longer.
However I've recently noted that my comments on his videos, of which I've viewed hundreds and shared with others, have strangely disappeared. I can only assume edited out.
This despite being supportive. For example, in one ~3 days ago on mRNA vaccine which caused the thing it tries to prevent, I quoted that Govt evidence shows the covid vaccine increased covid by up to 3.5x.
If such supportive comments are unwanted for some reason, I will unsubscribe and stop recommending the site.
There is very little vitamin D3 in food, including foods fortified with vitamin D3 (vitamin D2 is less effective than D3, and is often used in fortified food).
Vitamin De can be produced in substantial quantities from UV-B exposure of ideally white skin, but this is not naturally available all year round to most people who live far from the equator, since it requires high elevation sunlight without cloud, glass, clothing or sunscreen. Furthermore, UV-B skin exposure always damages DNA and so raises the risk of skin cancer. In a given day, there is no extra benefit of being exposed to about 1/3 of the amount of UV-B which is required to redden the skin.
Consequently, most people cannot be fully healthy without proper vitamin D3 supplementation. The quantities are small, but are 5 to 10 times what most medical professionals think is adequate, because they are only aiming for 20 ng/mL circulating 25-hydroxyvitamin D which is sufficient to supply the kidneys.
Please see the research on the vitamin D compounds and the immune system cited and discussed at: https://vitamindstopscovid.info/00-evi/. This includes recommendations for how much vitamin D3 to supplement in order to attain this. The amount depends on body weight, with higher ratios of body weight for those suffering from obesity.
These are the recommendations of New Jersey based Professor of Medicine, Sunil Wimalawansa, as recently published in an article co-written by two other long-time vitamin D researchers, one also a professor of medicine and the other a professor of pediatrics: https://www.mdpi.com/2072-6643/16/22/3969
People suffering from obesity needing more supplemental vitamin D3 as a ratio of bodyweight to attain at least 50 ng/mL circulating 25-hydroxyvitamin D are detailed here: https://5nn.info/temp/250hd-obesity/. Obesity reduced the hydroxylation of vitamin D3 cholecalciferol in the liver to the circulating 25-hydroxyvitamin D the immune system needs and the excess adipose tissue absorbs this circulating25-hydroxyvitamin D.
0.125 mg (5000 IU) vitamin D3 a day on average is sufficient for 70 kg 154 lb body weight without obesity.
Without proper vitamin D3 supplementation such as this, most people - at least in winter - have half or less (down to 1/10th) of the 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D they need to be healthy.
"5000 IUs a day" sounds like a lot, but it is 1/8000th of a gram = 1 gram every 22 years. Pharma grade vitamin D3 costs about USD$2.50 a gram ex-factory. A credit card weighs 5 grams.
25-hydroxyvitamin D (calcifediol AKA "calcidiol") is made, primarily in the liver, from ingested or UV-B -> skin produced vitamin D3 cholecalciferol. This takes several days and only about 1/4 of ingested vitamin D3 is hydroxylated to become circulating 25-hydroxyvitamin D, as measured in "vitamin D" blood tests.
Neither of these compounds act as hormones. They are not signaling molecules. The immune system does not use hormonal signaling.
Many types of immune cell need a good supply of 25-hydroxyvitamin D in order to run their intracrine (inside each cell) and paracrine (to nearby cells) signaling systems, which are crucial to the cell's ability to respond to its changing circumstances.
Not long after lockdown in Aus ended, I took my teenage daughter for blood tests - iron etc. when we went back to results I asked what her Vit D levels were. I was told they no longer test for that in a general panel of bloods due to Government directive. The GP went on to say that Vit D levels are only relevant in old age / brittle bones
Yes, I recently asked my doctor to check and she said no, as they routinely assume everyone is deficient. However, they also warn that excess is toxic--how is one to determine proper dosage?
The haplotypes of the mitochondria in different populations will determine the coupling effects in cellular processes linked to Vitamin D synthesis and the environment a person is best suited. If you have a coupled type living near the equator is best or you will need to mitigate with other strategies like lamps, etc. It also makes a difference in the type of diet you eat. I would highly recommend having Dr. Jack Kruse on. He is a plethora of knowledge Dr. Campbell.
I have been disgusted with the "Vitamin D is Rat Poison" brigade (the word is used deliberately) to the extent that I published my only post on it.
https://open.substack.com/pub/cynical1984/p/vitamin-d-fraud?utm_source=share&utm_medium=android&r=1pfv8f
When you engage, they don't reason, they just spout nonsense.
As far as I am concerned it is inflammatory hyperbole combined with deliberate factual inaccuracies designed to put the trusting reader off taking supplements. The game plan appears to be ANY supplements.
Now, I don't pretend all supplements are high quality and ethical by any means, but these people are LYING.
cholecalciferol is an effective poison.
"For possum control, cholecalciferol has been used as the active ingredient in lethal baits. The LD50 is 16.8 mg/kg, but only 9.8 mg/kg if calcium carbonate is added to the bait. Kidneys and heart are target organs. LD50 of 4.4 mg/kg has been reported in rabbits, with lethality to almost all rabbits ingesting doses greater than 15 mg/kg. Toxicity has been reported across a wide range of cholecalciferol dosages, with LD50 as high as 88 mg/kg or LDLo as low as 2 mg/kg reported for dogs."
https://en.wikipedia.org/wiki/Cholecalciferol
Well, Karl,
If you want to consider yourself a possum thats fine by me. You seem to have the mental capacity of one, at best.
hey, if you want to eat rat poison, that's fine with me. (we all gotta believe in something, I guess)
"The presence of excessive amount of vitamin D3 in commercial feed supplements reported causing toxicity especially in pets, swine and human infants"
https://www.researchgate.net/publication/252063370_Cholecalciferol_Vitamin_D3_toxicity_in_animals
"Toxic doses of cholecalciferol are much lower than reported acute lethal doses (13 mg/kg) and median lethal doses (88 mg/kg), and important clinical changes with notable morbidity, even mortality, may be noted with relatively low doses. Therefore the acute lethal dose and median lethal dose are recognized, but they are rarely used in guiding aggressive care and monitoring in companion animal patients. Clinical signs may be noted in doses as low as 0.1 mg/kg, with appreciable elevations in calcium and phosphorus concentrations leading to metastatic soft tissue mineralization in doses exceeding 0.5 mg/kg."
https://www.merckvetmanual.com/toxicology/rodenticide-poisoning/cholecalciferol-vitamin-d3-poisoning-in-animals
Karl, the fact cholecalciferol can be used as a rodenticide does not make it ipso facto a rat poison.
You seem to blithely ignore the simple fact we produce the EXACT same chemical endogenously every time we step out into the sun (physiology willing, and despite Bill Gates).
Do me the courtesy of reading my single post on this matter, reply to the points therein, or shut up.
well, the same companies (big pharma) produce the chemical and sell it both as a rat poison and a human supplement. the recommended levels of this chemical in our blood was suddenly changed in 2011 and that's when the human supplement market took off. here's an article about how it started and who's behind it (yes, it's big pharma).
https://archive.ph/G6diM#selection-381.0-385.143
ok, I'll read your article.
Get back to me when you have.
And make sure you address the endogenous production of rat poison by healthy humans in order to STAY healthy, please.
Amazingly !!! good YouTube video by John Campbell - the best ever? I am an MD aa well as a PhD. I do have suggestions for John Campbell about people to interview but how can I come in direct contact with him?
One of whom is a Swedish MD PhD and "vitamin D enthusiast" with published papers in the field. And the others two psychology PhD:s and professors from Canada an New Zealand with many published papers on "nutrition" and mental disorders.
Now 77. Began supplementing with daily 5k iu D3 plus K2 in 2020. Blood level rose to 50 ng/ml within a few months. Now at 74 ng/ml. No vaxes of any kind for 20 plus years. No respiratory illnesses except mild case of Covid last fall temp ~100 and tired for a week.
I live on the equator so you would think D would be plentiful, but at altitude there is so much cloud cover that everyone takes D. It's sold everywhere... supermarkets, drug stores, shops and bodegas. They are large orange tablets that dissolve in water like an Alma Seltzer or Fizzie. C, D and Zinc. It's a once a day ritual here. I also spend twenty minutes a day with a Vitamin D lamp. Are the lamps considered effective? Amazon has several to choose from in the $19. range.
https://genervter.substack.com/p/lnps-und-modrna
Dear Dcotor Campbell, I can only ask you to translate this German article:
It is the first part, which deals exclusively with the pharmacokinetics of LNPs and modRNA. The second part, which is currently in progress (220+ studies and reviews by now and still no end inside), will provide a ruthless assessment of pharmacodynamics and a discussion of whether this technology should ever have been unleashed on humanity:
I got a vitamin D3 & K2 combination. I am a huge fan of your work. My maternal grandmother’s maiden name was Campbell.
Thanks for all your help.
A random comment John but have you read Deadly Medicines and Organised Crime: How Big Pharma Has Corrupted Healthcare By Peter Gotzsche?
When I had my Aorta replaced the surgeon said. “Your vitamin D is so good for someone of your age”. “What do you do”. I replied I’m always in the sun and drink cows milk and eat cheese.
https://odysee.com/@hipsterious:3/The-Vitamin-Psyop:2