Covid vaccines and multiple sclerosis

MS in these cases is 'very likely' vaccine caused

Well, I must say I was a little surprised to find this article, indicating a likely causative correlation between Covid vaccinations and Multiple Sclerosis on an official World Health Organisation website.

While this study is only dealing with a small number of cases, it could be considered to be inconsistent with the official narrative, one might even say the official international mantra, which I guess we all know by heart now that the vaccines are ‘safe and effective’. Or as we are now only too well aware, that they are not very effective and multiple adverse reactions including death have been clearly documented.

Nonetheless, the World Health Organisation are to be complimented on allowing this conversation to enter into the public domain. Let’s just hope it’s not a form of controlled opposition to give the impression of transparency.

This article is essentially saying that there is ‘cross-reactivity’ between the body’s response to the vaccine induced SARS coronavirus to spike protein and myelin sheaths, which protect the nerve fibres within the central nervous system.

The sequence of events would be roughly as follows.

Messenger RNA is injected into the body within lipid nanoparticles, (LNPs)

These lipid nanoparticles enter various cells and take over the cell’s protein producing apparatus to produce billions of copies of the spike protein which are then exported from the cells.

As these artificially synthesised spike proteins are now outside of the cells, their presence is detected by the immune system which recognises them as a foreign protein. (That is, it recognises them as antigens.) As a result, the immune system will commence the protective immune response.

Part of this immune response is that there is identification of a small population of T-helper cells (CD4+ T cells)which are able to recognise the presence of the antigen.

Once this T-helper lymphocyte has been identified as helpful, many millions of copies will be required. Therefore, this particular line of T helper cells will divide and proliferate. This will produce a large population of descendent specific T helpers to generate the immunological response.

Because these cells have derived from the original T helper cells that interacted with the antigen, they all share the same DNA based genetic information and are therefore described as a clonal group. This clonal group of T-helper cells will then produce various cytokines which will stimulate other components of the immune system. For example, the T-helper cells will stimulate the B lymphocytes to produce the antigen specific antibodies.

(Antibodies are the proteins that the immune system produces in order to neutralise the antigen, in this case a coronavirus spike protein.)

The problem is as well as interacting with the SARS coronavirus spike protein as they are supposed to, the T-helper cells also initiate an immune response to the myelin sheath within the central nervous system. If the myelin sheaths within the central nervous system are damaged this is referred to as demyelinating disease and of course the classic example of this pathology is multiple sclerosis.

Although the prognosis of multiple sclerosis is highly variable, often being characterised by relapses and remission of neurological symptoms, the overall trajectory of the disease moves towards greater degrees of paralysis.

So, what all this means is that as a result of the artificial synthesis of spike protein, the body generates an immunological reaction. However, this immunological reaction also damages the body’s own tissues. It generates a self-immune reaction, that is an autoimmune disease.

Unfortunately, a pathologically sensitised immune system is well capable of precise targeted attacks on a particular tissue throughout the body. In this case attacking the myelin sheaths around the nerve fibres in different parts of the central nervous system. Both the brain and the spinal cord can be affected.

In military terms this could be considered analogous to ‘friendly fire’ where our own forces are the ones that damage our own side.

This is the paper from the WHO site:

Covid-19 vaccination can induce multiple sclerosis via cross-reactive CD4+ T cells recognizing SARS-CoV-2 spike protein and myelin peptides

https://pesquisa.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/pt/covidwho-2138820?lang=en

It points out that both natural infection and the mRNA-based vaccinations can be accompanied by transient autoimmune phenomena. In some people, a new autoimmune disease can be caused.

The study considers two cases of multiple sclerosis (MS), confirmed with clinical and new radiological signs. Both cases presented shortly after mRNA-based vaccinations.

Self-reactive (autoimmune) T cells were detected from Spike specific T cell population. However, these T cells also reacted to myelin basic protein (MBP) which is an abundant protein in central nervous system (CNS) myelin. MBP has long been studied as a factor in the pathogenesis of the autoimmune neurodegenerative disease multiple sclerosis (MS). The researchers also found self-reaction to myelin oligodendrocyte glycoprotein (MOG) peptides, which have previously been implicated in MS. (Remember the oligodendrocytes are the myelin producing cells in the central nervous system.)

The study concluded

Detailed studies of both peripheral blood, and CSF (cerebrospinal fluid) derived T helper cells (CD4+ T cells) show that the onset of MS in these two cases is very likely caused by CD4+ T cell clones. These cells cross-recognize SARS-CoV-2 S protein derived peptides and peptides derived from myelin proteins, which have previously been implicated in MS.

This new WHO paper is consistent with work from January 2022 published in the Journal of Neuroimmunology:

New diagnosis of multiple sclerosis in the setting of mRNA COVID-19 vaccine exposure (January 2022)

https://pubmed.ncbi.nlm.nih.gov/34922126/

This reported three cases of newly diagnosed MS following exposure to mRNA COVID-19 vaccine. They did caution that the association cannot be determined to be causal. However, they went on to report a series of 5 cases of newly diagnosed MS following recent exposure to mRNA COVID-19 vaccines. This 2022 paper concluded that acute neurological deficits in the setting of recent mRNA COVID-19 vaccine administration may represent new onset multiple sclerosis.

My final question

How many other cases are unrecognised or unreported is a question for coming months and years.

Sketch of the pathology

In this diagram we see the T cell which has been sensitised by the spike proteins induced by the vaccine. The immune response that the T-cell then generates will attack the spike proteins and also attack spike proteins on a virus, which this person may subsequently infect the individual. However, the immune response then goes on to mistake certain proteins on the surface of the myelin sheath surrounding the nerve fibres, in the central nervous system, for spike protein. This is because the two protein types can have a similar molecular architecture. The end result is this autoimmune response damages the myelin sheath causing demyelination, which is the prime pathology in multiple sclerosis.